Anti-metastatic and Anticancer Potentials of Synthesized Chalcones in B16-F10 Melanoma Cells Induced Metastatic Lung Cancer in C57BL/6 Mice

Abstract: Aim/Background: Metastasis is the main reason of death in cancer with a key challenge to target it precisely by available treatments. The current study was designed assess anti-metastatic potentials synthesized chalcones, Ch-1 and Ch-2. Materials Methods: In vitro included cytotoxicity, scratch wound assay cell cycle analysis vivo performed C57BL/6 mice B16-F10 induced metastatic lung model. Results: found be potent cytotoxic agent on lines namely, MCF-7 (human breast cells), (melanoma Hela (cervical cells) HEK embryonic kidney IC50 < 100 μM. deterred G2/M phase cycle, S Phase HeLa G0-G1 cycle. Scratch cells Ch-2 showed significant (p<0.05) prevention their multiplication when compared untreated at both 24 h 48 intervals. that, oral administration mg/kg b.w. reduced nodules 77.32%. Standard drug Quercetin inhibited tumor nodule formation 56.5%. However, except for WBC count, (100 mg/kg) also displayed improvement hematological profile. No difference any groups animals mean body weight major organ weight. Conclusion: Study supports possible use as potential anticancer cancer. Key words: Chalcones, Anticancer, melanoma cells, Metastatic cancer, Cell Cycle.